Addendum to my previous post. Outside of China, there are ~505 cases and... 2 deaths. That's about a .39% death rate.
-
The Sietch will be brought offline for HPG systems maintenance tomorrow (Thursday, 2 May 2024). Please remain calm and do not start any interstellar wars while ComStar is busy. May the Peace of Blake be with you. Precentor Dune
China Wuhan Virus Pandemic
- Thread starter Arch Dornan
- Start date
As others mentioned previously, those statistics are too small and too heavy on very early cases (while deaths happen in late ones) to say anything.
Floridaman
Well-known member
So is this the new plague? Forget Tom Clancy, we have been teleported into Fallout.
Duke Nukem
Hail to the king baby
This is so surreal, It's like something out of a resident evil movie or something
Terthna
Professional Lurker
I think it's too early to make that conclusion; the next few weeks could change things drastically.
Arch Dornan
Oh, lovely. They've sent me a mo-ron.
The price of rushing a hospital to completion.
I had the feeling that, while not a bio-engineered weapon, it was bio-engineered for some other reason. Maybe vaccine research or something else commercially-related in the future, I don't know.
As always with something to do with China, they fucked it up.
But no, calling out something China-related for being cheap, poorly-made, skimping/cutting corners, or their just being fucking incompetent or outright assholish outside of their ability to steal other people's shit because that's what the Chinese fucking do makes me a "Sinophobe".
And now look at the result of Chinese incompetence. A fucking dangerous virus spreading world-wide that's killed people.
Fucking China.
As always with something to do with China, they fucked it up.
But no, calling out something China-related for being cheap, poorly-made, skimping/cutting corners, or their just being fucking incompetent or outright assholish outside of their ability to steal other people's shit because that's what the Chinese fucking do makes me a "Sinophobe".
And now look at the result of Chinese incompetence. A fucking dangerous virus spreading world-wide that's killed people.
Fucking China.
Tiamat
I've seen the future...
Calling that a "hospital" is a misnomer. It's a sloppily-constructed ward built for PR purposes, again, at best. There's no isolation of patients, an apparent lack of proper medical equipment, and with the leaks that's going to create a very quick mold risk on top of the already current risk of infections. Viruses and bacteria and other goodies always love wet humid environments. They're basically packing the civilians in there to die.
I'm not so sure that'll happen, but I'd be all aboard for that.
I love my Chinese wife and her family, but yeah, there's a big difference between them and those folks still back 'in the old country.' What concerns me is lets say this gets here with rates of infection higher than what we have presently? I could see politics rearing its ugly head with any quarentine.
There is no good answer here. At the very least? This thing is going to kill hundreds of thousands in the PRC IMO. I cannot say for the rest of the world, but this is a damn tragedy. It's made worse by a system that in every major crisis historically, it has managed to kill millions of its own people. This will be no different.
Last edited:
Arch Dornan
Oh, lovely. They've sent me a mo-ron.
Anyone heard of discussion where the virus may affect fertility?
PsihoKekec
Swashbuckling Accountant
I don't think China will notice that effect.
Duke Nukem
Hail to the king baby
Jesus Christ.
I started posting this in coronavirus general on /pol/:
I just wanted to see how people would react to it. I was also hoping to marshal the resources of anons, maybe get them to donate to vital, lifesaving medical research.
You know what happened?
Oh my god. They don't want people to know.
- The OPs stopped having links to previous threads, to deflect views away from my posts.
- Shills started furtively posting mocking shit at me about how Todd Rider is a fraud and should have been able to secure a loan or venture capital if he was so good, even though he's an MIT scientist who is published in a peer-reviewed journal and his decades-old invention has already been proven to work.
- Shill activity in the threads decreased substantially, with more posts by legitimate posters. In other words, the threads were still bumped by interested people, but they started moving more slowly because the shills bowed out of the threads temporarily.
You know what this virus does to people?
That is the fate of millions of Americans - hell, millions of people, everywhere - if we don't bring this under control.
People on /pol are. A bunch of assholes, I wouldn't expect anything reasonable from them at all.
Morphic Tide
Well-known member
Okay, this was my main skepticism of it being possible. Though as an enzyme, of sorts, I wouldn't trust it with every virus, and I'd also have the testing phase very specifically include fertility checks and pregnancy in as many stages and as many species as possible since there's a possibility it bricks some forms of cell mitosis, especially since it does bind to DNA, or triggers a false positive on the various ultra-large proteins.
In particular, Titan/Connectin has a total number of amino acids of over 27,000, which means it quite possibly has over 80,000 base pairs (if I recall the ratio of three base pairs to one amino acid properly). Helpfully, the version in mice is longer, so one could use them for long-term testing in case this issue applies.
Arch Dornan
Oh, lovely. They've sent me a mo-ron.
Jesus Christ.
I started posting this in coronavirus general on /pol/:
I just wanted to see how people would react to it. I was also hoping to marshal the resources of anons, maybe get them to donate to vital, lifesaving medical research.
You know what happened?
Oh my god. They don't want people to know.
- The OPs stopped having links to previous threads, to deflect views away from my posts.
- Shills started furtively posting mocking shit at me about how Todd Rider is a fraud and should have been able to secure a loan or venture capital if he was so good, even though he's an MIT scientist who is published in a peer-reviewed journal and his decades-old invention has already been proven to work.
- Shill activity in the threads decreased substantially, with more posts by legitimate posters. In other words, the threads were still bumped by interested people, but they started moving more slowly because the shills bowed out of the threads temporarily.
You know what this virus does to people?
That is the fate of millions of Americans - hell, millions of people, everywhere - if we don't bring this under control.
Didn't work on Pol?
Last edited:
Morphic Tide
Well-known member
Further thoughts after actually reading the article and looking at more details than putting numbers to my concerns: Connectin has a theoretical half-life of 30 hours, so the 10-day duration of the DRACO protein would have caused the muscular destruction I was concerned with. No idea what to even try to search for to see about possible pregnancy and fertility problems.
The article lays out that, as humans don't have double-stranded RNA of over 23 base pairs, it's set for over 30 base pairs to exclude known normal human function. The design of it is that it's apparently an RNA/DNA attachment group spliced to a protein group that, when two are bound adjacent as should occur exclusively on double-stranded genetic molecules that exceed 30 base pairs, triggers late stages of the apoptosis process, as most virises halt early stages, while this goes for bypassing those stages entirely to go after things very few viruses have any countermeasure for.
The question is which caspase DRACO activates, as there's a very real possibility for a poxvirus to be lurking out there that shuts down the way it induces apoptosis by blocking the particular caspase DRACO uses. However, that just means making a different version of it, unless the virus blocks all caspase activation, as the whole thing rests on the fact that the RNA binding and caspase triggering to induce apoptosis are very specific protein domains that you can just LEGO together as needed.
But that's mostly questions for future outbreaks. As-is, it cures existing cases of full-blown AIDs (though it takes some amount of time to do so, simply because the immune system has to grow back), which is a vast fuck of a lot more than anyone is honestly expecting.
The article lays out that, as humans don't have double-stranded RNA of over 23 base pairs, it's set for over 30 base pairs to exclude known normal human function. The design of it is that it's apparently an RNA/DNA attachment group spliced to a protein group that, when two are bound adjacent as should occur exclusively on double-stranded genetic molecules that exceed 30 base pairs, triggers late stages of the apoptosis process, as most virises halt early stages, while this goes for bypassing those stages entirely to go after things very few viruses have any countermeasure for.
The question is which caspase DRACO activates, as there's a very real possibility for a poxvirus to be lurking out there that shuts down the way it induces apoptosis by blocking the particular caspase DRACO uses. However, that just means making a different version of it, unless the virus blocks all caspase activation, as the whole thing rests on the fact that the RNA binding and caspase triggering to induce apoptosis are very specific protein domains that you can just LEGO together as needed.
But that's mostly questions for future outbreaks. As-is, it cures existing cases of full-blown AIDs (though it takes some amount of time to do so, simply because the immune system has to grow back), which is a vast fuck of a lot more than anyone is honestly expecting.
Morphic Tide
Well-known member
Yeah, that article is great. They really did a lot of testing to be sure each part did as predicted. They modified E. Coli to produce the protein, and checked 10 times the amount of proteins extracted from regular E. Coli just in case there was some wonder-drug contaminant and DRACO wasn't important. They checked each transduction tag separately to find which was most effective, and tested DRACO without it to be sure it actually needed the tags.
They used a name-brand helper-agent, which acted as advertised and improved uptake without any noted toxicity. They tested periods of administration at a variety of times, including confirming the results that it persisted for 8 days by administering the virus 6 days after DRACO, and found it useful up to 3 days after infection with rhinovirus 1b, after which point it lost effectiveness because of too many cells being infected, causing unacceptable levels of tissue damage from widespread apoptosis.
And they elaborate with mentioning other options for dsRNA binding domains, and other options for triggering apoptosis. They did their work very thoroughly to be sure their LEGO approach (again, it's stapling a dsRNA binding domain to a domain for triggering apoptosis) was, in fact, an accurate application of the biochemical theory.
They used a name-brand helper-agent, which acted as advertised and improved uptake without any noted toxicity. They tested periods of administration at a variety of times, including confirming the results that it persisted for 8 days by administering the virus 6 days after DRACO, and found it useful up to 3 days after infection with rhinovirus 1b, after which point it lost effectiveness because of too many cells being infected, causing unacceptable levels of tissue damage from widespread apoptosis.
And they elaborate with mentioning other options for dsRNA binding domains, and other options for triggering apoptosis. They did their work very thoroughly to be sure their LEGO approach (again, it's stapling a dsRNA binding domain to a domain for triggering apoptosis) was, in fact, an accurate application of the biochemical theory.
Well, they tested a lot of variations of it, and all came up non-toxic with an expected 8-day effective antiviral duration. And it only triggers apoptosis when it encounters sufficiently long genetic material, that being double-stranded RNA or DNA with more than 30 base pairs. And I bring up testing fertility impacts specifically because there's a real chance of it killing sperm production or early stages of embryonic development, possibly through to the end of the first trimester of pregnancy.