In an unusual subversion for a Japanese DnD-inspired fantasy, the Konosuba setting actually does take into account the implications a lot of the time (more so in the light novel than the anime):
Quests for picking herbs or other easily-gathered ingredients or items are almost impossible to find, due to the all the newbie adventurers having done them to the point where the ingredients/items simply aren't readily available anymore;
Adventurers needing to be a certain level to be allowed to go into the deep forests, since the monsters in there are far more dangerous than ones on the plains due to the latter being effectively and constantly culled by the adventurers doing quests close to cities or traveling between them;
Adventurers prefering to take "easy" quests that don't require lots of traveling, resulting in monsters in general being rare around cities and adventurers frequently hanging around a single city as their home base... where many of them invariably end up causing trouble due to boredom whenever there's a shortage of quests and the local Adventurers Guild taking it upon themselves, along with the local authorities, to "create" quests or events to keep them occupied and out of trouble;
A group of succubi turning sex dreams into a business, taking payment in the form of a tiny amount of life force (barely enough to make the client feel a little tired the next day) and money, the latter in order to pay for the house they use and partially to fund the day-time café they also run;
Said succubi inadvertently causing females in the city to wonder why the men aren't pursuing them for relationships as much as they used to and triggering the local authorities to launch an investigation... humorously ending in nothing after the prosecutor in charge finds out she can have all her Boys Love fantasies realized in the dreams offered by the succubi dream service, prompting her to declare the investigation found nothing;
A noble family getting their hands on a random monster-summoning item and using it to summon random monsters, selling the valuable ones to collectors and underground arena runners while releasing the not-so-valuable-but-still-dangerous ones into the wild, causing a massive increase in the local number of monsters... until they are found out and brought to justice;
The erection of a spirit-banishing magic circle in a local graveyard prompting the ghosts to start infesting surrounding inhabited buildings and causing way more problems than they did in the graveyard;
Rich nobles and royalty paying good money to have rare and powerful monsters slain and their parts brought in as ingredients that the nobles then eat themselves to get XP and raise their levels without putting themselves in danger;
A local magic shop failing due to only offering a combination of cheap-but-defective and useful-but-overly-expensive goods, adventurers rejecting the former and mostly unable to pay for the latter;
Repeated use of massively-powerful spells actually causing changes to the local landscape (and law enforcement practices);
Basic magic spells for summoning water, earth, etc being used by farmers for mundane purposes such as filling fields with mineral-rich earth and fresh, clean water;
The main character, Kazuma, being constantly disappointed with having all his isekai expectations subverted by the fantasy world actually taking implications into account and people having adapted accordingly.
...And those are just off the top of my head. If I took the time to re-read I'd probably find dozens more. Despite being a comedic and over-the-top setting, Konosuba actually gets a lot of things right that many more serious or down-to-Earth fantasy settings don't (lookin' at you, ASoIaF).