Though, there’s the problem in that you lose out in-terms of politics due to Democrats being the majority and that may continue decades from
now
You guys who differ can holdout till you can somehow secede
Not really.
If Trump wins re-election he almost certainly appoints one, and likely two, supreme court justices (RBG won't last another four years, Breyer is iffy, Thomas might also leave two or three years from now if Trump is still President). In addition, he will solidify the lower courts.
Whenever the Republicans hold the Senate (which they are naturally advantaged in), they can kill anything that the Democrats try at the federal level and keep the courts from swinging to the progressives.
At the state level, Republicans have the advantage when it comes to state legislatures and governors.
Going forward, Republicans also have the demographic advantage. Progressives have fewer kids, have more abortions, and rely on conversion as opposed to birth to build their political base. The Republicans have more kids, are opposed to abortion, and rely on birth to build their political base.
By 2060 the Mormons are probably going to be the single largest voting bloc in the US.
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Then you need to account for what is about to occur. If the Supreme Court ever gets around to squarely facing the standard of scrutiny question for the Second Amendment, gun rights becomes a settled political issue because the gun control crowd can't win on it. Overturning Roe (which has been a fifty year political effort to even make theoretically possible, and still probably won't occur) is far easier than overturning the second amendment being an individual right that has strict scrutiny applied to it would be. Especially when, as soon as SCOTUS decides the scrutiny question, there are going to be hundreds of challenges to gun control regimes in every circuit and state court; it is going to become thoroughly entrenched precedent in literally a handful of years. That removes a major social issue from regular political contention.
Then you have the economic and globalization issues. The US is already going isolationist, which is only going to accelerate. The US is also going to cease to be the consumer market of first and last resort for the rest of the world. Then you have the boomer retirement and what that is going to do for tax bases, government expenses, and capital markets the world over.
The long term trends actually favor the Republicans in the US, not the Democrats.