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Doubt it. A coronavirus seems a weird choice for a bioweapon. They're very, very, very mutagenic.

You could theoretically use something like Cas-9 to insert genes that increase pathogenicity, or cause toxicity in normally non harmful bacteria, or to make retroviruses more lethal to humans. But I wouldn't even know where to start when it came to something like designing a disease specifically...

You could maybe make up with sheer attrition. You can get very accurate mutations, with mutagenic compounds for sure. But then you're looking at more and more lab time being added on, with more and more testing for each permutation of each mutation. Which is just going to bloat and bloat the...

The solution then may be to pick multiple markers that intersect with enough of the theoretical target population to ensure over a certain percentage target kill/offtarget kill. You'd need pretty extensive intel on your target populations genomics as well, which I imagine isn't freely available...

An engineered disease isn't a normal infectious disease. There are probably characteristics within the Han Chinese genome that segregates them from any theoretical target population; things like phages can be as target sensitive as a few dozen base pairs; and still be extremely lethal to the...

Back to brutal land wars in Europe it is then.