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Here's the thing: a Galaxy-class from around when TNG ended was shown to be completely helpless when faced with three Dominion fighters not much larger than a runabout. The Defiant-class starships are purpose-built warships. The others are not.

Sisko has an advantage in that he got to look at and go "yea or nea" to the plans and specs before the Defiant was even laid down. The Defiant-class is his baby in ways that Kirk, Picard, and Janeway can't match.

I think Sisko and the Defiant are going to win. The Defiant is a pure warship designed by Sisko. The others aren't warships and don't have the designer - who knows all the strengths and weaknesses - in command and sitting in the Captain's chair.