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And salt laced with heavy metals and pesticides.

No known cases of doing it long term, especially not without the area looking like postapoclyptic wasteland, so I reckon it was due to contamination with particular chemical, it's possible the farmers themselves overdoing the use of the wrong kind of pesticide.

Industrial pollution.

Nature is fairly hardy, although Chinese managed to do stupid things like completely wiping out bees in some regions, so polination of crops and trees that require it has to be done by hand. It is not effective.