Also, remember when Randolph Carter metaphorically flipped off Nyarlat-frigging-hotep and not only lived to tell the tale, but all Nyarly could do later was brood and sulk over it?
And in Innsmouth the USN tears Y'ha-nthlei a new one with depth charges, and in Whisperer in Darkness a bunch of mi-go get killed by a guy with a shotgun.